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The Most Common Kratom Alkaloids

Daniel King

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While many people are learning more about Kratom and its potential, not as many are familiar with its chemical components. Getting a basic understanding of these components is a worthwhile endeavor. After all, the benefits that Kratom consumers report are directly related to its chemical composition! Before you buy Kratom online, it’s important to gain an understanding of how it works.

Studies about Kratom and how it affects the body have been centered around its alkaloids. Kratom alkaloids, which are naturally occurring compounds found in many plants, interact directly with the body, so understanding them gives a better understanding of Kratom in a more general sense.

Many people are familiar with Kratom’s main alkaloid, mitragynine, and maybe even with 7-hydroxymitragynine, which occurs in much smaller concentrations. But there are actually dozens of alkaloids in the Kratom plant. What are these alkaloids, and what do we know about them?

What Is Kratom?
Kratom is a tropical plant that grows in different regions of Southeastern Asia. The leaves from this tree are harvested in Thailand, Borneo, Malaysia, and other countries and then dried. The dried leaves can be used as a natural supplement, and they have been used this way for hundreds of years in these areas.

The leaves can be processed into tea, powder, or liquids for consumption. Kratom enthusiasts around the world use Kratom while seeking relief for a variety of symptoms.

What Are Kratom Alkaloids?
Kratom leaves have many different chemical compounds in them. All of these compounds are structurally different, which means that the effects they have on the body vary. The most well-known effects of Kratom are thought to be caused by mitragynine and 7-hydroxymitragynine.

These two compounds are only two of the many Kratom alkaloids that can be found in Kratom leaves. They are the most prominent because they bind the most readily with the body’s receptors, but that doesn’t mean that the other Kratom alkaloids should be ignored.

Breaking Down Kratom Alkaloids
To understand the potential of Kratom and products derived from it, let’s break down some of the alkaloids found in Kratom.

Mitragynine
One of the two most common alkaloids found in Kratom is mitragynine. Mitragynine is usually the primary alkaloid in Kratom. It accounts for up to 70% of the alkaloid content in Kratom leaves, and it has been studied in isolation for many years. It binds readily with important receptors in the body, which accounts for its reported effects.

7-hydroxymitragynine
This is the other most prominently active alkaloid found in Kratom.
7-hydroxymitragynine chemically similar to mitragynine, so it is often studied in relation for the reasons and in the same contexts. The amount of 7-hydroxymitragynine in Kratom leaves varies much more than that of mitragynine, though. The amount is dependent on the variety, drying procedure, and time of harvest but is always quite small, typically just fractions of a percent.

Paynantheine
Paynantheine is the Kratom alkaloid that makes up the second-highest amount of chemical compounds in the Kratom leaves. It is typically present in higher amounts than 7-hydroxymitragynine, but it is not as active in the human body. More research needs to be done about this alkaloid, but there is some information available at this time.

Speciogynine
The alkaloid with the third-highest concentration in most Kratom leaves is speciogynine, another alkaloid that is thought to have active effects in the human body. More research needs to be done about this substance as well.

Mitraphylline
Typically accounting for less than 1% of Kratom leaves, this alkaloid may act in many unique way on human physiology. Mitraphylline is believed to have a great deal of potential and it is an exciting candidate for additional studies.

Ajmalicine
Ajmalicine was one of the first alkaloids found in Kratom when studied in the 1970s in Southeastern Asia. This alkaloid is a receptor antagonist that may interact with parts of the body that regulate various functions.

Many, Many More
There are so many alkaloids found in Kratom leaves, and there are likely even more that have yet to be discovered. While those with the highest concentrations have the most direct effects through Kratom, even those with lower quantities can act in symbiosis with other alkaloids. More studies will need to be done to see if the alkaloids function with each other.
It will be very interesting to find out how much that is the case. In the case of CBD and cannabis products, it has been found that many chemical components of cannabis actually work together to have more profound effects on the body, sometimes called the entourage effect. Whether or not the same can be said about Kratom components is yet to be seen.

Studying Kratom Alkaloids
As you worked through the list of some of the 40+ alkaloids found in Kratom above, you likely noticed that many of the alkaloids have not been thoroughly researched.

Because the amounts of alkaloids in leaves vary so greatly, studying them individually needs to be done sooner rather than later. Alkaloid content in leaves varies based on geographic location, harvest time, technique, and much more.

If science makes it so that we have a better understanding of individual alkaloids and their effects on the body, we would be better able to diversify and understand different Kratom strains. We already know that the leaves’ strain color, for example, can possibly be linked to alkaloid content breakdown.

According to a study from the 1970s, the alkaloids found most frequently in one area were:
Mitragynine
Speciogynine
Speciociliatine
Paynantheine
Ajmalicine
C9 methoxy-oxindoles

When looking at other strains and other geographic locations, however, this breakdown varied tremendously. Many studies that did not analyze the alkaloid breakdown of Kratom may not equally apply to all strains, and that is a problem.

As we move forward with Kratom studies, we know how important it will be for individual alkaloids to be analyzed. There is a diverse world of alkaloids in the leaves of Kratom, and there may be great benefits hidden in those alkaloids.

Looking Forward With Kratom Alkaloids
While mitragynine and 7-hydroxymitragynine remain the most prominent and well-studied components of Kratom, there are many other alkaloids that may provide some real benefits. As we move forward, we can expect to see more research done about those components. Not only will they be useful in Kratom as a whole, natural substances, but those alkaloids could be developed into additional substances as well.

Only time and additional research will be able to show the true potential of Kratom alkaloids!

Kraken Kratom is a premier online vendor of high-quality Kratom products. They offer a wide variety of the most popular Kratom strains including Bali, Maeng Da, Gold Reserve, and others.

Benefits of Medical Marijuana

Ache No More: How to Use CBD Oil for Pain Relief

Daniel King

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CBD Oil For Pain

Chronic pain sufferers have a new medication to consume — CBD oil.

In a study published in Health Affairs, chronic pain topped the list of the common reasons people give when they enroll in medical marijuana programs and start using CBD. Even though the survey did not find out whether CBD really provides relief, it proved what many researchers have been saying for years — the plant is a potent medication for different types of pain such as arthritis and joint pain.

CBD Products as Medicine

The cannabis plant family, which includes hemp, produce two compounds that benefit health: cannabidiol (CBD) and tetrahydrocannabinol (THC). Both these compounds work by communicating with the endocannabinoid system, a group of receptors in the body responsible for regulating various physiological processes such as digestion, feeling, pain, and sleep.

While researchers found that both are potent in providing pain relief, more doctors prescribe pure CBD oil to their patients because of minimal harmful effects. Unlike THC, CBD has no psychoactive effect — meaning it does not affect one’s mental state. Hence, doctors and other healthcare practitioners prescribe it to most of their patients because of its host of healing and anti-inflammatory properties without the fear of nasty side effects.

Aside from relieving pain, other CBD oil benefits include relief for anxiety and depression, epilepsy, Alzheimer’s disease, glaucoma, and even cancer.

CBD Hemp Oil for Pain

Cannabidiol comes from either marijuana or hemp. Most of what you buy from dispensaries came from hemp. With the passing of the 2018 Farm Bill that legalizes the use of products derived from the plant, health experts believe the cannabidiol industry will boom further especially for patients.

CBD hemp oil relieves the pain from:

  • Arthritis
  • Cancer
  • Crohn’s disease
  • Fibromyalgia
  • Headaches
  • Irritable bowel syndrome
  • Migraines
  • Multiple sclerosis
  • Muscle cramps
  • Neuropathy
  • Osteoarthritis
  • Rheumatism
  • Temporomandibular disorder (often referred to as TMJ)

Many patients with these conditions take prescription medicine for immediate relief. But since the rise of cannabidiol products in the market, many patients have shifted to a more natural and safer treatment for their sufferings.

How to Consume Cannabidiol

There are many ways to consume cannabidiol. You can apply ointments, balms, or lotions directly to the affected area. You can also try cannabidiol tinctures, edibles, vapes, and capsules. With tinctures, you can drop the substance under your tongue or place it in your food. You can also eat edibles like chocolate bars, gummies, tea, and coffee. Vapers can also buy CBD vape oil. Some patients supplement cannabidiol capsules along with their multivitamins.

In most cases, putting on cannabidiol on the localized areas of pain can provide more consistent levels of the substance with less minimal body processes. The body still needs to undergo a lengthy process if they consume the cannabis-derived compound through the mouth or lungs. But for chronic pain emanating inside the body, the Mayo Clinic recommends 2.5mg to 20mg of cannabidiol oil consumed orally every day.

Where to Buy CBD Oil

You can buy the best CBD oil in reputable dispensaries or online stores. One online retailer that sells various CBD products for inflammation and arthritis is Simple Garden CBD.

There are many kinds of cannabis/cbd oil, each with a unique mixture. Some brands contain THC, which can affect your mood if you consume beyond the recommended dosage. Hence, to ensure you are getting the right dosage, you may need to consult with your doctor or a cannabis expert but before buying. You should also ask for guidance from budtenders or store attendants especially if you purchase CBD or cannabis products for the first time.

Cannabidiol is a natural painkiller with minimal side effects, unlike prescription drugs. Consult your doctor now to find out which product works best for your condition.

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Cannabis 101

Must-Dos Before, During and After Your Cannabis Dispensary Visit

Jordan Webber

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Cannabis Dispensary

With all the buzz around marijuana and hemp, more people are becoming curious about trying these products for themselves. This is why talking about the best ways to get your hands on these items has become all the more essential. If you are planning on going to a cannabis dispensary, here’s what you need to do before, during and after your visit:

Before Your Visit Cannabis Dispensary

Nothing beats the feeling of going to your trusted dispensary for a visit – aside from the feeling you get when you ingest your cannabis, of course! Whether you are a long-time enthusiast or a newbie to the cannabis world, keep in mind that it is always important to prepare for your dispensary visit. These are some of the things you should do before you go:

• Check Your State’s Marijuana Laws

There is no denying that this plant has been widely used in the United States for decades. However, recent changes to legislation have made the medicinal and recreational use of cannabis legal in a number of states. As of today, 33 states have legalized medicinal marijuana, 10 of which (with the addition of Washington, D.C.) allow its use for recreational purposes too. Moreover, cannabinoids such as cannabidiol (CBD) and a controlled amount of tetrahydrocannabinol (THC) are permitted in a majority of the states, except Idaho, South Dakota and Kansas. So, before you go to a dispensary, ensure that using this herb for your intended purpose is allowed in your state.

Cannabis Law on Each State

Once you are sure that possessing and using cannabis (and cannabinoids) for medicinal or recreational purposes is permitted in your state, you should take note of the specific details of such permissions. How much cannabis are you allowed to possess on your person? How about in your place of residence? Are you required to obtain an MMJ card before you can get your dose of cannabis? Keeping tabs on the policies can help give you peace of mind in knowing that you are aware of the fundamentals and on the right side of the law when purchasing this plant.

• Do Your Research

Another important step you should take before you travel to your dispensary is to do due diligence on such dispensary. Aside from knowing the law, you might want to do further research to make sure that your trip is worth all the effort. A quick look online to get the best marijuana dispensaries in your area is a good idea. Look for a local dispensary that operates legally, and that offers excellent products, services, and variety. The best way to do this is to scour the internet for reviews about a particular dispensary. Take note of what they have to offer, how their budtenders interact with customers and the overall quality of the shop.

You also need to make sure that you know how CBD and THC works. Basically, these compounds bind with the body’s cannabinoid receptors located in the central and peripheral nervous system, as well as in the digestive and immune systems. What’s fascinating is that our bodies have a natural endocannabinoid system and the compounds from the herb simply enhance its functions. It is also crucial to know that a 1:1 ratio of CBD and THC improves the effects of these two cannabinoids.

By knowing how cannabis works, you will be more confident about getting these products. This knowledge can also help you decide which products will best suit your needs to achieve the desired results.

• List Down Your Expectations

To guarantee that you get the effects you are aiming for, be sure of your needs and preferences. First, determine what you want to get from the product. Are you looking to take advantage of cannabis’ medicinal properties? Or do you simply want it for the recreational effects it offers? This will help you determine what kind of item to get.

For the dispensary itself, you might want to set a time and place that is amenable to your schedule. A word of caution though, you might want to set aside more time for your visit, especially if you are getting medical marijuana. Just like regular medical clinics, these places can have licensed medical practitioners who will conduct consultations, and these can take time.

• Bring These Essentials

When heading out to the dispensary of your choice, you want to ensure that your visit will be successful. To guarantee that you will be going home with goodies in your bag, make sure that you have these with you before you leave home:

o An ID – In states where recreational cannabis is legal, dispensaries are only permitted to distribute these products to people 21 years old and over. The dispensary may require their customers to present identification cards, so see to it that you bring one that shows your date of birth.

o Your MMJ Card – For people under the age of 21 and in need of medicinal cannabis, make sure that you have your doctor’s recommendation. If you are a patient who incorporates this herb into your medical routine, make a point of having your MMJ card with you.

o Cash – Bear in mind that this herb remains illegal federally. Hence many banks and financial service companies prohibit transactions involving marijuana. If you are thinking of going cashless, reconsider this plan and go with cash instead.

During Your Visit

So, you found a place that has great reviews, and you are ready to go. While you are there, you want to make sure that you get the best product. Check out these helpful tips on how to pick the cannabis item that perfectly suits your taste:

• Survey the Selections

With the variety of cannabis products available on the market, these shops are likely to carry a wide selection of items. Take the time to see which of these items might suit you the best. You may find a combination of dried buds, baked goods, and cannabinoid extracts. Decide for yourself the intake method you prefer. Is it the old-school way of smoking a joint? Or perhaps you want to give your experience a delicious twist and get cannabis-infused food products.

Whatever your thoughts, if you ever get confused and overwhelmed, do not hesitate to get help from the budtender. Remember, these people know the items they are selling, and they are there to assist you on your journey.

• Dig Deeper

You may have decided to get, say, the dried buds. You’ve found the type of product you think you might like. But remember, there is more to marijuana than meets the eye. You still need to decide which strain will certainly hit the spot for you. Again, your budtender will be your best source of information if you’re unsure of what to get. If you are looking for a body high, their staff is likely to recommend an indica-based strain, while they can suggest getting a sativa-dominant variety for a head high.

• Go Beyond the Mainstream

Aside from getting mainstream products like dried buds, baked goods, and extracts, you can also get more artisanal ones. From finely made cannabis-infused chocolates and coffees to vape juices and cosmetic items mixed with cannabinoids, you can be as adventurous as you like when choosing a product.

After Your Visit

Congratulations! You have just purchased your cannabis item! You must be excited to consume your newly-purchased goodies. However, the best experience comes when you make the most of these products. Need help? See to it that you keep these pointers in mind:

• Pick the Best Time

You want to make sure that your intake will work to your advantage, so it’s important to pick an optimal time for your consumption. If you want a brain high, it is likely that you purchased a CBD-rich item. These products are great for daytime, especially for mornings, as they will boost your energy and creativity levels. For those who work in the afternoon or at night, you can also ingest it before you start.

On the other hand, THC-rich treats give you a body high based on its sedative, relaxing and euphoric effects, making it better to consume these products during your downtime or before you rest.

• Take it Slow

The cannabis experience may vary, depending on the individual. For some, just one hit gives them the effect they are looking for, while for others, it takes time to show results. If you do not get the feeling you are looking for, take our word of advice: avoid taking it all in one go! Give it time to work its magic, and sure enough, you will feel its effects. This way, you are not getting more of a dose than intended, and you will be practicing healthy and safe consumption.

• Enjoy Your Cannabis!

Lastly, the best advice we can give you is just sit back (or get up!) and enjoy the goodness cannabis provides. This way, you can take advantage of what the plant has to offer without worries. Who knows, you might be on your way to becoming a cannabis enthusiast if you aren’t one already.

Along with the push to legalize cannabis, the call for proper education on procuring these items is on the rise. This helpful guide is a valuable resource to a smarter, safer and more effective way to avail of and use these products, allowing you to benefit from this wonderful plant.

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Cannabis Lifestyle

How ‘Someone Great’ Normalized Women Consuming Weed

Stacey Wellington

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Women using Weed

For the longest time, there was a societal misconception that only men had the right and the ability to use weed. Often, stoner films and even musicians centered on male personalities who have been taking this herb. As a matter of fact, these films show men huddling around and passing their joint to one another, as well as sharing their marijuana with fellow weed enthusiasts.

Today, it cannot be denied that the use of cannabis and even CBD Hemp oil has already been normalized in society, albeit far and few in between. After all, having a daily dose of pure cannabidiol or a hit of a joint is no different from having a glass of wine to relax, particularly after a long day. Someone Great, Netflix’s newest film is showing viewers just how women are taking back their space and showing the use of weed in their everyday life.

Setting the Pace

Television shows have already featured strong female personalities who have used cannabis. In fact, the characters of Abbi Jacobson and Ilana Glazer in Broad City have had numerous adventures with this plant. One of these hilarious escapades includes Ilana transporting cannabis and keeping it safe under her lady bits.

Mary + Jane from MTV also takes pride in showing two strong women breaking through a male-dominated weed delivery company in Los Angeles. Even Disjointed featured a commanding female presence through a cannabis activist who runs her own dispensary, perfectly depicted by Kathy Bates.

A More Relatable Approach

While these shows paved the way for the plant and the many CBD hemp oil benefits to become known, it seems that the film Someone Great appears more relatable, particularly for women who are not only experiencing a breakup but also those who are going through overwhelming changes in life.

Here, the character of Gina Rodriguez, the protagonist of the breakup comedy named Jenny, is finally moving from the Big Apple to sunny San Francisco. Having recently broken up with her boyfriend of nine years, Jenny makes it a point to leave the city with a bang. To do this, she meets with her two girlfriends, Erin (DeWanda Wise) and Blair (Brittany Snow) and goes on a series of wild exploits throughout Manhattan.

What makes these 20-something women relatable, apart from their kinship and their struggles, is their love for pot. As they began their thrilling journey around the city, each of these female characters either smokes up a joint or inhale the vapor of their CBD oil vape pen. Whether it be having sexual trysts or doing some work and grinding it up, this film illustrates that women are still capable of doing whatever they set their mind do even while taking cannabis.

This Netflix movie successfully showed using weed has become more accepted not only in society but also as a part of people’s lifestyle. In many ways, this has also become akin to taking a generous serving of wine at night, particularly when it comes to relaxing.

Various Uses of Cannabis

Jenny, Erin, and Blair all showed how they used cannabis in their life. Come to think of it, while each of these characters used it hastily, all of these individuals benefited from taking this herb. One enjoyed sex better, one became more relaxed and equipped in dealing with work, and so on.

Apart from using these in non-traditional ways, cannabis can also be used to alleviate pain and to treat a variety of illnesses and health concerns. The market now has CBD oil for pain management, CBD beauty products, and so on, thus upping the hemp game of the industry.

Someone Great shows that women are also adept with dealing with cannabis on screen. More than this, the film depicts a sense of rawness and relatability that allows viewers to see for themselves that weed does not have to be shunned. Give it a go and see just how eye-opening this movie can be.

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